Rayos: (Prednisone) Delayed-release Tablets

Full Prescribing Information For Patients

The first and only delayed-release prednisone
for the treatment of RA and PMR

RAYOS® (prednisone) delayed-release tablets are indicated in the treatment of the following diseases
or conditions:

1.1 Allergic Conditions

Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in adults and pediatric populations with:

  • Atopic dermatitis
  • Drug hypersensitivity reactions
  • Seasonal or perennial allergic rhinitis
  • Serum sickness

1.2 Dermatologic Diseases

  • Bullous dermatitis herpetiformis
  • Contact dermatitis
  • Exfoliative erythroderma
  • Mycosis fungoides
  • Pemphigus
  • Severe erythema multiforme (Stevens-Johnson syndrome)

1.3 Endocrine Conditions

  • Congenital adrenal hyperplasia
  • Hypercalcemia of malignancy
  • Nonsuppurative thyroiditis
  • Primary or secondary adrenocortical insufficiency: hydrocortisone or cortisone is the first choice: synthetic analogs may be used in conjunction with mineralocorticoids where applicable

1.4 Gastrointestinal Diseases

During acute episodes in:

  • Crohn's Disease
  • Ulcerative colitis

1.5 Hematologic Diseases

  • Acquired (autoimmune) hemolytic anemia
  • Diamond-Blackfan anemia
  • Idiopathic thrombocytopenic purpura in adults
  • Pure red cell aplasia
  • Secondary thrombocytopenia in adults

1.6 Neoplastic Conditions

For the treatment of:

  • Acute leukemia
  • Aggressive lymphomas

1.7 Nervous System Conditions

  • Acute exacerbations of multiple sclerosis
  • Cerebral edema associated with primary or metastatic brain tumor, craniotomy or head injury

1.8 Ophthalmic Conditions

  • Sympathetic ophthalmia
  • Uveitis and ocular inflammatory conditions unresponsive to
    topical steroids

1.9 Conditions Related to Organ Transplantation

  • Acute or chronic solid organ rejection

1.10 Pulmonary Diseases

  • Acute exacerbations of chronic obstructive pulmonary
    disease (COPD)
  • Allergic bronchopulmonary aspergillosis
  • Aspiration pneumonitis
  • Asthma
  • Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate chemotherapy
  • Hypersensitivity pneumonitis
  • Idiopathic bronchiolitis obliterans with organizing pneumonia
  • Idiopathic eosinophilic pneumonias
  • Idiopathic pulmonary fibrosis
  • Pneumocystis carinii pneumonia (PCP) associated with hypoxemia occurring in an HIV(+) individual who is also under treatment with appropriate anti-PCP antibiotics.
  • Symptomatic sarcoidosis

1.11 Renal Conditions

  • To induce a diuresis or remission of proteinuria in nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus

1.12 Rheumatologic Conditions

As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in:

  • Acute gouty arthritis

During an exacerbation or as maintenance therapy in selected
cases of:

  • Ankylosing spondylitis
  • Dermatomyositis/polymyositis
  • Polymyalgia rheumatica
  • Psoriatic arthritis
  • Relapsing polychondritis
  • Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low dose maintenance therapy)
  • Sjogren's syndrome
  • Systemic lupus erythematosus
  • Vasculitis

1.13 Specific Infectious Diseases

  • Trichinosis with neurologic or myocardial involvement.
  • Tuberculous meningitis with subarachnoid block or impending block used concurrently with appropriate antituberculous chemotherapy.

CONTRAINDICATIONS

  • Known hypersensitivity to prednisone or any excipients in the formulation
  • WARNINGS AND PRECAUTIONS

  • Corticosteroids can cause hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing's syndrome and hyperglycemia. Monitor patients for these conditions with chronic use. Taper doses gradually for withdrawal after chronic use
  • RAYOS may increase susceptibility to new infection and increase risk of exacerbation, dissemination or reactivation of latent infection. RAYOS may mask signs and symptoms of infection. The rate of infectious complications increases with increasing doses of corticosteroids
  • Corticosteroids can cause elevated blood pressure, salt and water retention and hypokalemia. Monitor blood pressure and sodium, potassium serum levels. RAYOS should be used with caution in patients with a history of recent myocardial infarction, congestive heart failure, hypertension or renal insufficiency
  • There is an increased risk of gastrointestinal (GI) perforation in patients with certain GI disorders. RAYOS may mask signs and symptoms of GI perforation
  • Corticosteroid use may be associated with behavioral and mood disturbances, including euphoria, insomnia, mood swings, personality changes, severe depression and psychosis. Existing conditions may be aggravated
  • Corticosteroid use may lead to inhibition of bone growth in children and adolescents and the development of osteoporosis at any age. Give special consideration to patients at increased risk of osteoporosis (eg, postmenopausal women) before initiating corticosteroid therapy, and bone density should be monitored in patients on long-term corticosteroid therapy
  • Prolonged use of corticosteroids may result in cataracts, infections and glaucoma. Monitor intraocular pressure if corticosteroid therapy is continued for more
    than 6 weeks
  • Do not administer live or attenuated vaccines to patients receiving immunosuppressive doses of corticosteroids
  • Long‐term use of corticosteroids can have negative effects on growth and development in children. Monitor pediatric patients on long‐term corticosteroid therapy
  • Fetal harm can occur with first trimester use of corticosteroids. Apprise women of potential harm to the fetus
  • ADVERSE REACTIONS

  • Common adverse reactions for corticosteroids include fluid retention, alteration in glucose tolerance, elevation in blood pressure, behavioral and mood changes, increased appetite and weight gain
  • INDICATIONS AND USAGE

    RAYOS is a corticosteroid indicated:
  • As an anti-inflammatory or immunosuppressive agent for certain allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, specific infectious diseases or conditions and organ transplantation
  • For the treatment of certain endocrine conditions
  • For palliation of certain neoplastic conditions
  • For a complete list of indications for RAYOS, please see the full Prescribing Information.

    For further information on RAYOS, please see full Prescribing Information at www.RAYOSrx.com/PI.

    *For eligible patients. Terms and Conditions apply. Please click here for more information.

    All rights reserved © 2014 Horizon Pharma USA, Inc.
    RAYOS is a registered trademark of Horizon Pharma.
    May 2014. 0109RAY01
    www.horizonpharma.com